Sequence Detail

ID/Version

Q96EQ9 B8JJZ8 Q0D2N4 (UniProt | EBI)

Last sequence update: 2009-02-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase PRDM9 {ECO:0000305};AltName: Full=Hybrid sterility protein 1;AltName: Full=Meiosis-induced factor containing a PR/SET domain and zinc-finger motif;AltName: Full=PR domain zinc finger protein 9;AltName: Full

Provider

SWISS-PROT

Sequence

Polypeptide 843 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prdm9	PR domain containing 9	81	103	4	36

Sequence references in MGI

J:102875 Hayashi K, et al., A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature. 2005 Nov 17;438(7066):374-8
J:143556 Mihola O, et al., A mouse speciation gene encodes a meiotic histone h3 methyltransferase. Science. 2009 Jan 16;323(5912):373-5
J:180577 Grey C, et al., Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination. PLoS Biol. 2011 Oct;9(10):e1001176
J:215270 Koh-Stenta X, et al., Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques. Biochem J. 2014 Jul 15;461(2):323-34
J:233373 Powers NR, et al., The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo. PLoS Genet. 2016 Jun;12(6):e1006146
J:250814 Sun F, et al., Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis. Chromosoma. 2015 Sep;124(3):397-415
J:255344 Diagouraga B, et al., PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA Double-Strand Break Formation at Its Binding Sites. Mol Cell. 2018 Mar 1;69(5):853-865.e6
J:267768 Tian H, et al., CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse. PLoS Genet. 2018 Oct;14(10):e1007657
J:277855 Parvanov ED, et al., PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell. 2017 Feb 1;28(3):488-499
J:277873 Wu H, et al., Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9. Cell Rep. 2013 Oct 17;5(1):13-20
J:290204 Huang T, et al., The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair. Elife. 2020 May 6;9:e53459