Sequence Detail

ID/Version

Q925J9 Q6AXD5 Q8BX19 O88323 A2A528 Q3UHV0 A2A526 Q8VDQ7 Q925K0 Q8BW37 (UniProt | EBI)

Last sequence update: 2005-12-06
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mediator of RNA polymerase II transcription subunit 1;AltName: Full=Mediator complex subunit 1;AltName: Full=Peroxisome proliferator-activated receptor-binding protein; Short=PBP; Short=PPAR-binding protein;AltName: Full=Thyr

Provider

SWISS-PROT

Sequence

Polypeptide 1575 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Med1	mediator complex subunit 1	212	116	3	37

Sequence references in MGI

J:43438 Zhu Y, et al., Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem. 1997 Oct 10;272(41):25500-6
J:61840 Ito M, et al., Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell. 2000 Apr;5(4):683-93
J:70827 Ehringer MA, et al., High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63
J:76817 Ge K, et al., Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature. 2002 May 30;417(6888):563-7
J:86857 Landles C, et al., The Thyroid Hormone Receptor-Associated Protein TRAP220 Is Required at Distinct Embryonic Stages in Placental, Cardiac, and Hepatic Development. Mol Endocrinol. 2003 Dec;17(12):2418-35
J:92973 Malik S, et al., Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol. 2004 Sep;24(18):8244-54
J:94123 Jia Y, et al., Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem. 2004 Jun 4;279(23):24427-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118300 Stumpf M, et al., The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18504-9
J:201135 Lande-Diner L, et al., A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16021-16026
J:222684 Wansa KD, et al., The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003 Jul 4;278(27):24776-90
J:289911 Zhang Y, et al., USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination. J Exp Med. 2020 May 4;217(5)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89