Sequence Detail

ID/Version

Q924Z4 Q9DCN6 Q3TXC5 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ceramide synthase 2 {ECO:0000303|PubMed:18165233}; Short=CerS2 {ECO:0000303|PubMed:18165233};AltName: Full=LAG1 longevity assurance homolog 2 {ECO:0000303|PubMed:15823095};AltName: Full=Sphingosine N-acyltransferase CERS2 {ECO:000030

Provider

SWISS-PROT

Sequence

Polypeptide 380 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cers2	ceramide synthase 2	40	105	4	49

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117553 Mizutani Y, et al., Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263-71
J:156841 Imgrund S, et al., Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem. 2009 Nov 27;284(48):33549-60
J:161189 Pewzner-Jung Y, et al., A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem. 2010 Apr 2;285(14):10902-10
J:197105 Yamashita-Sugahara Y, et al., Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor gamma target gene that regulates adipogenesis through ceramide synthesis. J Biol Chem. 2013 Feb 15;288(7):4522-37
J:230048 Novgorodov SA, et al., SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22;291(4):1957-73
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297974 Yang Y, et al., LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins. Biochem Biophys Res Commun. 2020 Jun 11;526(4):871-879
J:352590 Zhu Q, et al., PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels. Nat Metab. 2024 Jul;6(7):1347-1366