Sequence Detail

ID/Version

Q923J1 A2AI58 Q8C7S7 Q925B2 Q9CUT2 Q921Y5 Q9JLQ1 Q8CE54 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transient receptor potential cation channel subfamily M member 7; EC=2.7.11.1 {ECO:0000269|PubMed:11161216, ECO:0000269|PubMed:24855944, ECO:0000269|PubMed:25030553, ECO:0000269|PubMed:29203869};AltName: Full=Channel-kinase 1;AltName

Provider

SWISS-PROT

Sequence

Polypeptide 1863 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trpm7	transient receptor potential cation channel, subfamily M, member 7	85	116	3	32

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:140630 Jin J, et al., Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31;322(5902):756-60
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:181963 Jin J, et al., The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E225-33
J:200702 Sah R, et al., Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3037-46
J:205665 Ryazanova LV, et al., TRPM7 is essential for Mg(2+) homeostasis in mammals. Nat Commun. 2010;1:109
J:221252 Kaitsuka T, et al., Inactivation of TRPM7 kinase activity does not impair its channel function in mice. Sci Rep. 2014;4:5718
J:222132 Krapivinsky G, et al., The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Cell. 2014 May 22;157(5):1061-72
J:258392 Romagnani A, et al., TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut. Nat Commun. 2017 Dec 4;8(1):1917
J:272317 Mittermeier L, et al., TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival. Proc Natl Acad Sci U S A. 2019 Feb 15;
J:272346 Schappe MS, et al., Chanzyme TRPM7 Mediates the Ca(2+) Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation. Immunity. 2018 Jan 16;48(1):59-74.e5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:321349 Schutz A, et al., Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos. Cell Rep. 2021 Oct 19;37(3):109851
J:352408 Duan J, et al., Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8201-E8210
J:352409 Abiria SA, et al., TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6079-E6088
J:354154 Nadler MJ, et al., LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature. 2001 May 31;411(6837):590-5
J:355633 Ferioli S, et al., TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg.ATP. Sci Rep. 2017 Aug 18;7(1):8806