Sequence Detail

ID/Version

Q922U2 Q920F2 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Keratin, type II cytoskeletal 5;AltName: Full=Cytokeratin-5; Short=CK-5;AltName: Full=Keratin-5; Short=K5;AltName: Full=Type-II keratin Kb5;

Provider

SWISS-PROT

Sequence

Polypeptide 580 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Krt5	keratin 5	28	187	3	19

Sequence references in MGI

J:76311 Peters B, et al., Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex. Mol Biol Cell. 2001 Jun;12(6):1775-89
J:83640 Ravindranath RM, et al., Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth. J Biol Chem. 2003 May 30;278(22):20293-302
J:138481 Spazierer D, et al., Stress-induced recruitment of epiplakin to keratin networks increases their resistance to hyperphosphorylation-induced disruption. J Cell Sci. 2008 Mar 15;121(Pt 6):825-33
J:214772 Fischer H, et al., Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. J Invest Dermatol. 2014 Oct;134(10):2579-88
J:229462 Allen EH, et al., Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy. Hum Mol Genet. 2016 Mar 15;25(6):1176-91
J:272927 Inaba H, et al., Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase. Biochem Biophys Res Commun. 2018 Apr 6;498(3):544-550
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297664 Simonson L, et al., Keratin 13 deficiency causes white sponge nevus in mice. Dev Biol. 2020 Dec 1;468(1-2):146-153
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:322687 Bouameur JE, et al., Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure. J Invest Dermatol. 2014 Nov;134(11):2776-2783
J:322809 Roth W, et al., Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex. Hum Mutat. 2009 May;30(5):832-41