Sequence Detail

ID/Version

Q922D8 Q8R013 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=C-1-tetrahydrofolate synthase, cytoplasmic {ECO:0000305|PubMed:15611115}; Short=C1-THF synthase;Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase {ECO:0000305|PubMed:15611115}; EC=1.5.1.5 {ECO:0000269|PubMed:

Provider

SWISS-PROT

Sequence

Polypeptide 935 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mthfd1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	68	111	5	63

Sequence references in MGI

J:76037 Patel H, et al., Mammalian mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase derived from a trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase. Arch Biochem Biophys. 2002 Jul 1;403(1):145-8
J:97251 Christensen KE, et al., Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria. J Biol Chem. 2005 Mar 4;280(9):7597-602
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89