Sequence Detail

ID/Version

Q921N8 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=G protein pathway suppressor 2 {ECO:0000303|PubMed:22424771}; Short=GPS-2 {ECO:0000303|PubMed:22424771};

Provider

SWISS-PROT

Sequence

Polypeptide 327 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gps2	G protein pathway suppressor 2	40	96	3	7

Sequence references in MGI

J:135288 Zhang D, et al., G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. J Biol Chem. 2008 Mar 28;283(13):8580-90
J:219351 Guo C, et al., The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2. J Biol Chem. 2015 Feb 6;290(6):3666-79
J:224604 Huang J, et al., Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31;290(31):19044-54
J:239857 Fan R, et al., Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nat Med. 2016 Jul;22(7):780-91
J:240887 Lentucci C, et al., Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17;292(7):2754-2772
J:243390 Liu XF, et al., ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PLoS One. 2012;7(5):e38130
J:259113 Cardamone MD, et al., GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARgamma. Cell Rep. 2014 Jul 10;8(1):163-76
J:259114 Cardamone MD, et al., Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 Mar 1;69(5):757-772.e7
J:259118 Cardamone MD, et al., A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13;46(1):91-104
J:260026 Cederquist CT, et al., Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 Jan;6(1):125-137
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87