Sequence Detail

ID/Version

Q91ZX7 Q61291 Q920Y4 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2026-09-02

Sequence description from provider

RecName: Full=Prolow-density lipoprotein receptor-related protein 1 {ECO:0000305}; Short=LRP-1;AltName: Full=Alpha-2-macroglobulin receptor; Short=A2MR;AltName: CD_antigen=CD91;Contains: RecName: Full=Low-density lipoprotein receptor-rela

Provider

SWISS-PROT

Sequence

Polypeptide 4545 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lrp1	low density lipoprotein receptor-related protein 1	175	133	4	43

Sequence references in MGI

J:4760 Van Leuven F, et al., Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA. Biochim Biophys Acta. 1993 Apr 29;1173(1):71-4
J:30077 Herz J, et al., LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation [published erratum appears in Cell 1993 May 7;73(3):428]. Cell. 1992 Oct 30;71(3):411-21
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:273590 Muramatsu H, et al., LDL receptor-related protein as a component of the midkine receptor. Biochem Biophys Res Commun. 2000 Apr 21;270(3):936-41
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292724 Rauch JN, et al., LRP1 is a master regulator of tau uptake and spread. Nature. 2020 Apr;580(7803):381-385
J:344260 Yan W, et al., Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2203557119
J:362021 Kakogiannos N, et al., GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system. J Clin Invest. 2024 Jun 6;134(15)