Sequence Detail

ID/Version

Q91ZV8 B2RRK0 (UniProt | EBI)

Last sequence update: 2009-01-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Adhesion G protein-coupled receptor A2 {ECO:0000305};AltName: Full=G-protein coupled receptor 124 {ECO:0000303|PubMed:21071672};AltName: Full=Tumor endothelial marker 5 {ECO:0000303|PubMed:11559528};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1336 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adgra2	adhesion G protein-coupled receptor A2	46	102	3	15

Sequence references in MGI

J:71592 Carson-Walter EB, et al., Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001 Sep 15;61(18):6649-55
J:143398 Homma S, et al., Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr Patterns. 2009 Jan;9(1):1-26
J:166127 Kuhnert F, et al., Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12;330(6006):985-9
J:169064 Anderson KD, et al., Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12
J:171226 Cullen M, et al., GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
J:222817 Posokhova E, et al., GPR124 functions as a WNT7-specific coactivator of canonical beta-catenin signaling. Cell Rep. 2015 Jan 13;10(2):123-30
J:243770 Zhou Y, et al., Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Dev Cell. 2014 Oct 27;31(2):248-56
J:251212 Chang J, et al., Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat Med. 2017 Apr;23(4):450-460
J:256044 Cho C, et al., Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron. 2017 Aug 30;95(5):1056-1073.e5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89