Sequence Detail

ID/Version

Q91ZR5 Q4PZC3 Q4PZD2 Q4PZC6 Q4PZC5 Q4PZC4 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cation channel sperm-associated protein 1; Short=CatSper1;

Provider

SWISS-PROT

Sequence

Polypeptide 686 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Catsper1	cation channel, sperm associated 1	46	107	2	8

Sequence references in MGI

J:72046 Ren D, et al., A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9
J:86971 Carlson AE, et al., CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14864-8
J:116406 Qi H, et al., All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1219-23
J:118812 Marquez B, et al., Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm. Dev Biol. 2007 Mar 1;303(1):214-21
J:123481 Liu J, et al., CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem. 2007 Jun 29;282(26):18945-52
J:128548 Carlson AE, et al., Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem. 2005 Sep 16;280(37):32238-44
J:153173 Wang H, et al., A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biol Reprod. 2009 Sep;81(3):539-44
J:182472 Chung JJ, et al., A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11;2:153
J:314092 Lin S, et al., Structure of a mammalian sperm cation channel complex. Nature. 2021 Jul;595(7869):746-750
J:321418 Hwang JY, et al., C2cd6-encoded CatSpertau targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Cell Rep. 2022 Jan 18;38(3):110226
J:354398 Lishko PV, et al., Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91