Sequence Detail

ID/Version

Q91ZP3 Q9JLG6 Q9CQI2 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phosphatidate phosphatase LPIN1 {ECO:0000305}; EC=3.1.3.4 {ECO:0000269|PubMed:17158099};AltName: Full=Fatty liver dystrophy protein {ECO:0000303|PubMed:11138012};AltName: Full=Lipin-1 {ECO:0000303|PubMed:19717560};

Provider

SWISS-PROT

Sequence

Polypeptide 924 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lpin1	lipin 1	59	99	4	17

Sequence references in MGI

J:66739 Peterfy M, et al., Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet. 2001 Jan;27(1):121-4
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102156 Peterfy M, et al., Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. J Biol Chem. 2005 Sep 23;280(38):32883-9
J:118160 Harris TE, et al., Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J Biol Chem. 2007 Jan 5;282(1):277-86
J:120935 Donkor J, et al., Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem. 2007 Feb 9;282(6):3450-7
J:129744 Finck BN, et al., Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 2006 Sep;4(3):199-210
J:156973 Donkor J, et al., A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. J Biol Chem. 2009 Oct 23;284(43):29968-78
J:159054 Liu GH, et al., Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS One. 2009;4(9):e7031
J:169933 Huang H, et al., piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling. Dev Cell. 2011 Mar 15;20(3):376-87
J:180810 Han S, et al., Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 (Formerly TMEM188) Is the Metazoan Spo7p Ortholog and Functions in the Lipin Activation Pathway. J Biol Chem. 2012 Jan 27;287(5):3123-37
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89