Sequence Detail

ID/Version

Q91ZM2 Q05DJ7 O54867 Q91ZV5 Q792R7 Q91ZM3 Q9WVM5 (UniProt | EBI)

Last sequence update: 2008-03-18
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=SH2B adapter protein 1;AltName: Full=Pro-rich, PH and SH2 domain-containing signaling mediator; Short=PSM;AltName: Full=SH2 domain-containing protein 1B;AltName: Full=SH2-B PH domain-containing signaling mediator 1;

Provider

SWISS-PROT

Sequence

Polypeptide 756 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sh2b1	SH2B adaptor protein 1	20	97	3	14

Sequence references in MGI

J:45715 Wang J, et al., Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter. J Biol Chem. 1998 Feb 6;273(6):3136-9
J:46214 Riedel H, et al., PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor. J Biochem. 1997 Dec;122(6):1105-13
J:58754 Nelms K, et al., Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. Mamm Genome. 1999 Dec;10(12):1160-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:129837 Ren D, et al., Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab. 2005 Aug;2(2):95-104
J:200437 Hu J, et al., Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. J Mol Biol. 2006 Aug 4;361(1):69-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87