Sequence Detail

ID/Version

Q91ZD4 Q923Z8 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Vang-like protein 2;AltName: Full=Loop-tail protein 1;AltName: Full=Loop-tail-associated protein;AltName: Full=Van Gogh-like protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 521 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Vangl2	VANGL planar cell polarity 2	120	150	3	37

Sequence references in MGI

J:70272 Kibar Z, et al., Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet. 2001 Jul;28(3):251-5
J:72911 Murdoch JN, et al., Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet. 2001 Oct 15;10(22):2593-601
J:74156 Henderson DJ, et al., Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant. Circ Res. 2001 Jul 6;89(1):6-12
J:83127 Montcouquiol M, et al., Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature. 2003 May 8;423(6936):173-7
J:95171 Torban E, et al., Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem. 2004 Dec 10;279(50):52703-13
J:105752 Wang Y, et al., The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci. 2006 Feb 22;26(8):2147-56
J:106431 Phillips HM, et al., Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res. 2005 Feb 18;96(3):292-9
J:108647 Montcouquiol M, et al., Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci. 2006 May 10;26(19):5265-75
J:163736 Yao R, et al., MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene. 2004 Aug 12;23(36):6023-30
J:191964 Belotti E, et al., Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes. PLoS One. 2012;7(9):e46213