Sequence Detail

ID/Version

Q91Z67 B2RY13 Q3V1V8 Q61054 (UniProt | EBI)

Last sequence update: 2007-01-09
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=SLIT-ROBO Rho GTPase-activating protein 2 {ECO:0000303|PubMed:11672528}; Short=srGAP2 {ECO:0000303|PubMed:11672528};AltName: Full=Formin-binding protein 2;AltName: Full=Formin-binding protein 27 {ECO:0000303|PubMed:8605874};

Provider

SWISS-PROT

Sequence

Polypeptide 1071 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Srgap2	SLIT-ROBO Rho GTPase activating protein 2	81	102	5	59

Sequence references in MGI

J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
J:72329 Wong K, et al., Signal transduction in neuronal migration. roles of gtpase activating proteins and the small gtpase cdc42 in the slit-robo pathway. Cell. 2001 Oct 19;107(2):209-21
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:153892 Guerrier S, et al., The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell. 2009 Sep 4;138(5):990-1004
J:184956 Mason FM, et al., Bi-modal regulation of a formin by srGAP2. J Biol Chem. 2011 Feb 25;286(8):6577-86
J:185134 Charrier C, et al., Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. Cell. 2012 May 11;149(4):923-35
J:239710 Fossati M, et al., SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses. Neuron. 2016 Jul 20;91(2):356-69
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319958 Fritz RD, et al., SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion. Dev Cell. 2015 Oct 12;35(1):78-92