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Sequence Detail
Q91YX0 Q3U5K5 (UniProt | EBI) Last sequence update: 2005-08-30
Last annotation update: 2021-09-29
from provider
RecName: Full=Protein THEMIS2 {ECO:0000305};AltName: Full=Induced by contact to basement membrane 1 protein {ECO:0000303|PubMed:20644716}; Short=Protein ICB-1;AltName: Full=Thymocyte-expressed molecule involved in selection protein 2;
Polypeptide 663 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Themis2 thymocyte selection associated family member 2 11 85 3 10
Sequence references in MGI J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:151074 Fu G, et al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009 Aug;10(8):848-56
J:151076 Johnson AL, et al., Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol. 2009 Aug;10(8):831-9
J:189787 Lesourne R, et al., Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol. 2012 Aug 1;189(3):1154-61
J:232061 Hartweger H, et al., Themis2 is not required for B cell development, activation, and antibody responses. J Immunol. 2014 Jul 15;193(2):700-7
J:259481 Cheng D, et al., Themis2 lowers the threshold for B cell activation during positive selection. Nat Immunol. 2017 Feb;18(2):205-213
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory