Sequence Detail

ID/Version

Q91Y86 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase 8; Short=MAP kinase 8; Short=MAPK 8; EC=2.7.11.24 {ECO:0000269|PubMed:11562351, ECO:0000269|PubMed:11602244, ECO:0000269|PubMed:16166642, ECO:0000269|PubMed:16618812, ECO:0000269|PubMe

Provider

SWISS-PROT

Sequence

Polypeptide 384 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mapk8	mitogen-activated protein kinase 8	136	182	4	35

Sequence references in MGI

J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
J:61895 Dong C, et al., JNK is required for effector T-cell function but not for T-cell activation. Nature. 2000 May 4;405(6782):91-4
J:64817 Ito M, et al., JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. Mol Cell Biol. 1999 Nov;19(11):7539-48
J:77616 Whitmarsh AJ, et al., Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 2001 Sep 15;15(18):2421-32
J:77628 Yang D, et al., Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3004-9
J:101360 Kadoya T, et al., JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Mol Cell Biol. 2005 Oct;25(19):8619-30
J:126838 Ye B, et al., GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. FEBS Lett. 2007 Sep 18;581(23):4403-10
J:165016 Lee CM, et al., JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14189-94
J:170348 Westerlund N, et al., Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat Neurosci. 2011 Mar;14(3):305-13
J:186089 Yoshitane H, et al., JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 2012 May;13(5):455-61
J:205863 Cunningham CA, et al., The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. Eur J Immunol. 2013 Dec;43(12):3361-71
J:251887 Song N, et al., NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017 Oct 5;68(1):185-197.e6
J:259122 Bae KB, et al., Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. Stem Cell Reports. 2017 Dec 12;9(6):2050-2064
J:261832 Cunningham CA, et al., POSH Regulates CD4+ T Cell Differentiation and Survival. J Immunol. 2016 May 15;196(10):4003-13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:334841 Kuramoto K, et al., Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise. Cell Metab. 2023 Feb 14;