Sequence Detail

ID/Version

Q91XM9 F8VQM7 Q8BXK7 Q8BYG5 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Disks large homolog 2;AltName: Full=Channel-associated protein of synapse-110; Short=Chapsyn-110;AltName: Full=Postsynaptic density protein PSD-93;

Provider

SWISS-PROT

Sequence

Polypeptide 852 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dlg2	discs large MAGUK scaffold protein 2	82	100	3	9

Sequence references in MGI

J:77016 Inanobe A, et al., Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1396-403
J:84686 Tao YX, et al., Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J Neurosci. 2003 Jul 30;23(17):6703-12
J:87449 Parker MJ, et al., PSD93 regulates synaptic stability at neuronal cholinergic synapses. J Neurosci. 2004 Jan 14;24(2):378-88
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114113 Leyland ML, et al., An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. J Biol Chem. 2004 Oct 15;279(42):43427-36
J:145953 Ng D, et al., Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol. 2009 Feb 24;7(2):e41
J:157696 Ogawa Y, et al., ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J Neurosci. 2010 Jan 20;30(3):1038-48
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89