Sequence Detail

ID/Version

Q91WS2 Q8K0L4 C9W978 F8UKQ6 Q67EY0 (UniProt | EBI)

Last sequence update: 2007-08-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NACHT, LRR and PYD domains-containing protein 6 {ECO:0000305};AltName: Full=Angiotensin II/vasopressin receptor {ECO:0000303|PubMed:20923861};AltName: Full=Non-angiotensin-vasopressin receptor {ECO:0000303|PubMed:20923861}; Short=Non

Provider

SWISS-PROT

Sequence

Polypeptide 869 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrp6	NLR family, pyrin domain containing 6	100	97	4	15

Sequence references in MGI

J:82173 Albrecht M, et al., Identification of mammalian orthologs associates PYPAF5 with distinct functional roles. FEBS Lett. 2003 Mar 13;538(1-3):173-7
J:173245 Elinav E, et al., NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis. Cell. 2011 May 27;145(5):745-57
J:173352 Normand S, et al., Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9601-6
J:175503 Chen GY, et al., A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol. 2011 Jun 15;186(12):7187-94
J:186698 Anand PK, et al., NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature. 2012 Aug 16;488(7411):389-93
J:197406 Hu B, et al., Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9862-7
J:212020 Wlodarska M, et al., NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014 Feb 27;156(5):1045-59
J:220441 Herrera VL, et al., AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice. Physiol Genomics. 2011 Jan 7;43(1):32-42
J:227056 Wang P, et al., Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015 Nov 13;350(6262):826-30
J:227991 Levy M, et al., Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 2015 Dec 3;163(6):1428-43
J:233302 Birchenough GM, et al., A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science. 2016 Jun 24;352(6293):1535-42
J:242786 Ydens E, et al., Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes. J Neuroinflammation. 2015 Aug 08;12:143
J:254353 Seregin SS, et al., NLRP6 Protects Il10(-/-) Mice from Colitis by Limiting Colonization of Akkermansia muciniphila. Cell Rep. 2017 Apr 25;19(4):733-745
J:255177 Mamantopoulos M, et al., Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition. Immunity. 2017 Aug 15;47(2):339-348.e4
J:260352 Galvez EJC, et al., Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure. Cell Rep. 2017 Dec 26;21(13):3914-3926
J:267416 Hara H, et al., The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018 Oct 26;
J:295244 Ghimire L, et al., NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function. PLoS Pathog. 2018 Sep;14(9):e1007308
J:299605 Sateriale A, et al., The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2007807118
J:306372 Mukherjee S, et al., Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nat Immunol. 2020 Jun;21(6):626-635
J:316943 Shen C, et al., Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 Nov 11;184(23):5759-5774.e20
J:319675 Lemire P, et al., The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition. Cell Rep. 2017 Dec 26;21(13):3653-3661