Sequence Detail

ID/Version

Q91WR5 Q6P8V0 Q9CX32 (UniProt | EBI)

Last sequence update: 2008-03-18
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Aldo-keto reductase family 1 member C21; EC=1.1.1.-;AltName: Full=17-alpha-hydroxysteroid dehydrogenase; Short=17-alpha-HSD;AltName: Full=3(or 17)-alpha-hydroxysteroid dehydrogenase; EC=1.1.1.209;AltName: Full=3-alpha

Provider

SWISS-PROT

Sequence

Polypeptide 323 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Akr1c21	aldo-keto reductase family 1, member C21	48	97	4	4

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117645 Faucher F, et al., Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. J Mol Biol. 2006 Dec 8;364(4):747-63
J:122578 Faucher F, et al., Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J Mol Biol. 2007 Jun 1;369(2):525-40
J:184960 Ishikura S, et al., Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family. Biol Pharm Bull. 2004 Dec;27(12):1939-45
J:240451 Dhagat U, et al., Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme. Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):198-204
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89