Sequence Detail

ID/Version

Q91WF0 Q810E8 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Tafazzin {ECO:0000312|MGI:MGI:109626}; Short=Taz; EC=2.3.1.- {ECO:0000250|UniProtKB:Q16635};

Provider

SWISS-PROT

Sequence

Polypeptide 262 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tafazzin	tafazzin, phospholipid-lysophospholipid transacylase	29	99	3	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:167527 Acehan D, et al., Cardiac and skeletal muscle defects in a mouse model of human barth syndrome. J Biol Chem. 2011 Jan 14;286(2):899-908
J:176041 Soustek MS, et al., Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency. Hum Gene Ther. 2011 Jul;22(7):865-71
J:187733 Phoon CK, et al., Tafazzin knockdown mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction. J Am Heart Assoc. 2012;1(2):jah3-e000455
J:192156 Acehan D, et al., Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion. 2009 Apr;9(2):86-95
J:238324 Cadalbert LC, et al., Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis. PLoS One. 2015;10(6):e0131066
J:270716 Cole LK, et al., Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3353-3367
J:289466 Kim J, et al., Cardiac mitochondrial structure and function in tafazzin-knockdown mice. Mitochondrion. 2018 Nov;43:53-62
J:290923 Powers C, et al., Diminished Exercise Capacity and Mitochondrial bc1 Complex Deficiency in Tafazzin-Knockdown Mice. Front Physiol. 2013;4:74
J:292961 Hsu P, et al., Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy. Autophagy. 2015 Apr 3;11(4):643-52