Sequence Detail

ID/Version

Q91WD2 (UniProt | EBI)

Last sequence update: 2015-04-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transient receptor potential cation channel subfamily V member 6; Short=TrpV6;AltName: Full=Calcium transport protein 1; Short=CaT1;AltName: Full=Epithelial calcium channel 2; Short=ECaC2;

Provider

SWISS-PROT

Sequence

Polypeptide 767 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trpv6	transient receptor potential cation channel, subfamily V, member 6	56	109	3	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113972 Hoenderop JG, et al., Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J. 2003 Feb 17;22(4):776-85
J:133151 Bianco SD, et al., Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res. 2007 Feb;22(2):274-85
J:163368 Lieben L, et al., Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis. Bone. 2010 Aug;47(2):301-8
J:192782 Woudenberg-Vrenken TE, et al., Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G879-85
J:203496 Fecher-Trost C, et al., The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG. J Biol Chem. 2013 Jun 7;288(23):16629-44