Sequence Detail

ID/Version

Q91WA9 Q8K4E1 Q8VBS9 (UniProt | EBI)

Last sequence update: 2004-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=ATP-binding cassette subfamily G member 4; EC=7.6.2.- {ECO:0000269|PubMed:15210959, ECO:0000269|PubMed:17916878, ECO:0000269|PubMed:18039927};AltName: Full=ATP-binding cassette transporter White2 {ECO:0000303|Ref.2};

Provider

SWISS-PROT

Sequence

Polypeptide 646 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abcg4	ATP binding cassette subfamily G member 4	44	103	4	6

Sequence references in MGI

J:75535 Annilo T, et al., Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. Cytogenet Cell Genet. 2001;94(3-4):196-201
J:78394 Yoshikawa M, et al., Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. Gene. 2002 Jun 26;293(1-2):67-75
J:78741 Oldfield S, et al., ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. Biochim Biophys Acta. 2002 Aug 19;1591(1-3):175-9
J:91401 Wang N, et al., ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9774-9
J:128847 Tarr PT, et al., ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. J Lipid Res. 2008 Jan;49(1):169-82
J:141549 Wang N, et al., ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J. 2008 Apr;22(4):1073-82
J:157050 Bojanic DD, et al., Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010 Jan;51(1):169-81
J:255568 Dodacki A, et al., Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-beta peptide. Sci Rep. 2017 Oct 17;7(1):13393