Sequence Detail

ID/Version

Q91W98 Q7TPL5 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Solute carrier family 15 member 4 {ECO:0000305};AltName: Full=Peptide/histidine transporter 1 {ECO:0000303|Ref.1};

Provider

SWISS-PROT

Sequence

Polypeptide 574 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc15a4	solute carrier family 15, member 4	44	97	3	12

Sequence references in MGI

J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:166600 Blasius AL, et al., Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19973-8
J:194543 Baccala R, et al., Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2940-5
J:194867 Blasius AL, et al., Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection. PLoS Pathog. 2012 Sep;8(9):e1002915
J:210445 Nakamura N, et al., Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature. 2014 May 8;509(7499):240-4
J:223449 Dosenovic P, et al., Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Immunol Cell Biol. 2015 Feb;93(2):136-46
J:241087 Wang XX, et al., A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice. Biochem Pharmacol. 2017 Jan 15;124:94-102
J:258080 Kobayashi T, et al., Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells. Int Immunol. 2017 Dec 31;29(12):551-566
J:264062 Hu Y, et al., SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages. J Immunol. 2018 Jul 15;201(2):652-662
J:270965 Sasawatari S, et al., The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology. 2011 May;140(5):1513-25
J:278269 Griffith AD, et al., A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. Sci Rep. 2018 Sep 27;8(1):14451
J:278429 Kobayashi T, et al., The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production. Immunity. 2014 Sep 18;41(3):375-388
J:278465 Wang XX, et al., Semi-Mechanistic Population Pharmacokinetic Modeling of L-Histidine Disposition and Brain Uptake in Wildtype and Pht1 Null Mice. Pharm Res. 2018 Jan 5;35(1):19
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292537 Lee J, et al., pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem. 2009 Aug 28;284(35):23818-29