Sequence Detail

ID/Version

Q91W10 Q9D5V4 Q8BTQ3 Q8BUD6 Q9D426 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Metal cation symporter ZIP8 {ECO:0000305|PubMed:16638970};AltName: Full=Solute carrier family 39 member 8 {ECO:0000312|MGI:MGI:1914797};AltName: Full=Zrt- and Irt-like protein 8 {ECO:0000303|PubMed:15722412}; Short=ZIP-8 {ECO:0000303

Provider

SWISS-PROT

Sequence

Polypeptide 462 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc39a8	solute carrier family 39 (metal ion transporter), member 8	111	109	3	23

Sequence references in MGI

J:96980 Dalton TP, et al., Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3401-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:125886 Wang B, et al., Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1523-35
J:212038 Kim JH, et al., Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell. 2014 Feb 13;156(4):730-43
J:244002 Lin W, et al., Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. J Clin Invest. 2017 Jun 01;127(6):2407-2417
J:258360 Lin W, et al., Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. J Clin Invest. 2018 Feb 1;128(2):826-833
J:278469 Galvez-Peralta M, et al., ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero. PLoS One. 2012;7(5):e36055
J:282595 Liu Z, et al., Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking. Biochem Biophys Res Commun. 2008 Jan 25;365(4):814-20
J:282611 Cheng G, et al., ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx. Int Immunopharmacol. 2018 Sep;62:203-211
J:282682 He L, et al., ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Mol Pharmacol. 2006 Jul;70(1):171-80
J:282723 McDermott JR, et al., Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake. Oncotarget. 2016 Jun 7;7(23):35327-40
J:308604 Geng X, et al., Role of ZIP8 in regulating cell morphology and NF-kappaB/Snail2 signaling. Metallomics. 2018 Jul 18;10(7):953-964
J:328866 Wang CY, et al., ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. J Biol Chem. 2012 Oct 5;287(41):34032-43