Sequence Detail

ID/Version

Q91VM4 Q5F242 B9A1T4 Q8R119 (UniProt | EBI)

Last sequence update: 2007-10-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sphingosine-1-phosphate transporter SPNS2 {ECO:0000305};AltName: Full=Protein spinster homolog 2 {ECO:0000305};AltName: Full=Spinster homolog 2 {ECO:0000303|PubMed:22664872}; Short=Spns2 {ECO:0000303|PubMed:22664872};

Provider

SWISS-PROT

Sequence

Polypeptide 549 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spns2	SPNS lysolipid transporter 2, sphingosine-1-phosphate	38	98	3	14

Sequence references in MGI

J:144229 Kawahara A, et al., The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science. 2009 Jan 23;323(5913):524-7
J:184558 Fukuhara S, et al., The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest. 2012 Apr 2;122(4):1416-26
J:188933 Nijnik A, et al., The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol. 2012 Jul 1;189(1):102-11
J:196347 Mendoza A, et al., The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. Cell Rep. 2012 Nov 29;2(5):1104-10
J:196984 Nagahashi M, et al., Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J. 2013 Mar;27(3):1001-11
J:228852 Chen J, et al., Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. PLoS Genet. 2014 Oct;10(10):e1004688
J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
J:319686 Goto H, et al., Direct uptake of sphingosine-1-phosphate (S1P) independent of phospholipid phosphatases. J Biol Chem. 2021 Mar 27;:100605
J:319866 Okuniewska M, et al., SPNS2 enables T cell egress from lymph nodes during an immune response. Cell Rep. 2021 Jul 13;36(2):109368