Sequence Detail

ID/Version

Q91VJ1 (UniProt | EBI)

Last sequence update: 2008-05-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interferon-inducible protein AIM2;AltName: Full=Interferon-inducible protein 210 {ECO:0000303|PubMed:15896773}; Short=Ifi-210 {ECO:0000303|PubMed:15896773};AltName: Full=Interferon-inducible protein p210 {ECO:0000303|PubMed:15896773}

Provider

SWISS-PROT

Sequence

Polypeptide 354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aim2	absent in melanoma 2	91	98	2	24

Sequence references in MGI

J:145965 Burckstummer T, et al., An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol. 2009 Mar;10(3):266-72
J:146958 Hornung V, et al., AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009 Mar 26;458(7237):514-8
J:147175 Fernandes-Alnemri T, et al., AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009 Mar 26;458(7237):509-13
J:158968 Fernandes-Alnemri T, et al., The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol. 2010 May;11(5):385-93
J:158969 Rathinam VA, et al., The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol. 2010 May;11(5):395-402
J:160545 Jones JW, et al., Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6
J:177982 Sauer JD, et al., Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host Microbe. 2010 May 20;7(5):412-9
J:181382 Belhocine K, et al., Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells. Cell Microbiol. 2012 Jan;14(1):71-80
J:187571 Roberts TL, et al., HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60
J:204790 Pierini R, et al., AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ. 2012 Oct;19(10):1709-21
J:205029 Ru H, et al., Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 2013 Jun;23(6):855-8
J:224547 Man SM, et al., Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. Cell. 2015 Jul 2;162(1):45-58
J:228671 Wilson JE, et al., Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat Med. 2015 Aug;21(8):906-13
J:235285 Di Micco A, et al., AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4671-80
J:236847 Hu B, et al., The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science. 2016 Nov 11;354(6313):765-768
J:254237 Dang EV, et al., Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017 Nov 16;171(5):1057-1071.e11
J:293308 Lammert CR, et al., AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment. Nature. 2020 Apr;580(7805):647-652
J:305800 Chou WC, et al., AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021 Mar;591(7849):300-305
J:331115 Wang LQ, et al., Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome. Nat Commun. 2021 May 18;12(1):2915
J:332982 Yin Q, et al., Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation. Cell Rep. 2013 Jul 25;4(2):327-39
J:361095 Lee S, et al., AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021 Sep;597(7876):415-419