Sequence Detail

ID/Version

Q91V51 Q543S4 Q91ZG1 Q8C0A2 Q3TGC8 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Polyglutamylase complex subunit TTLL1 {ECO:0000305}; EC=6.3.2.- {ECO:0000305|PubMed:15890843};AltName: Full=Tubulin polyglutamylase TTLL1;AltName: Full=Tubulin polyglutamylase complex subunit 3 {ECO:0000303|PubMed:15890843};

Provider

SWISS-PROT

Sequence

Polypeptide 423 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ttll1	tubulin tyrosine ligase-like 1	32	99	3	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130247 van Dijk J, et al., A targeted multienzyme mechanism for selective microtubule polyglutamylation. Mol Cell. 2007 May 11;26(3):437-48
J:161297 Ikegami K, et al., Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5
J:186050 Vogel P, et al., Tubulin tyrosine ligase-like 1 deficiency results in chronic rhinosinusitis and abnormal development of spermatid flagella in mice. Vet Pathol. 2010 Jul;47(4):703-12
J:201638 Bosch Grau M, et al., Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. J Cell Biol. 2013 Aug 5;202(3):441-51
J:241131 Janke C, et al., Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science. 2005 Jun 17;308(5729):1758-62
J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261
J:313952 Berezniuk I, et al., Cytosolic carboxypeptidase 1 is involved in processing alpha- and beta-tubulin. J Biol Chem. 2012 Feb 24;287(9):6503-17