Sequence Detail

ID/Version

Q91UZ4 Q3TCG8 Q8C8M6 Q8CCA8 Q8R5C7 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Prolyl hydroxylase EGLN3 {ECO:0000305}; EC=1.14.11.- {ECO:0000305|PubMed:24809345};AltName: Full=Egl nine homolog 3; EC=1.14.11.29 {ECO:0000250|UniProtKB:Q9H6Z9};AltName: Full=Hypoxia-inducible factor prolyl hydroxylase 3;

Provider

SWISS-PROT

Sequence

Polypeptide 239 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Egln3	egl-9 family hypoxia-inducible factor 3	37	105	3	19

Sequence references in MGI

J:60099 Moschella MC, et al., SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation. Gene Expr. 1999;8(1):59-66
J:72041 Taylor MS, Characterization and comparative analysis of the EGLN gene family. Gene. 2001 Sep 5;275(1):125-32
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:136034 Bishop T, et al., Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Mol Cell Biol. 2008 May;28(10):3386-400
J:153985 Minamishima YA, et al., A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol. 2009 Nov;29(21):5729-41
J:172036 Walmsley SR, et al., Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest. 2011 Mar 1;121(3):1053-63
J:232292 Scortegagna M, et al., Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May;10(5):e1004348