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Sequence Detail
Q8VIG1 Q3U0W0 A0JNY8 Q155C6 Q9CW43 Q4VAD6 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2020-04-22
from provider
RecName: Full=RE1-silencing transcription factor;AltName: Full=Neural-restrictive silencer factor;
Polypeptide 1082 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Rest RE1-silencing transcription factor 100 91 7 161
Sequence references in MGI J:23978 Schoenherr CJ, et al., The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science. 1995 Mar 3;267(5202):1360-3
J:24162 Chong JA, et al., REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell. 1995 Mar 24;80(6):949-57
J:50169 Chen ZF, et al., NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [see comments]. Nat Genet. 1998 Oct;20(2):136-42
J:57888 Palm K, et al., Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Brain Res Mol Brain Res. 1999 Sep 8;72(1):30-9
J:98945 Ballas N, et al., REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell. 2005 May 20;121(4):645-57
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:173128 Hata L, et al., Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. J Mol Cell Cardiol. 2011 Jun;50(6):972-81
J:208883 Lu T, et al., REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 Mar 27;507(7493):448-54
J:242726 Mukherjee S, et al., REST regulation of gene networks in adult neural stem cells. Nat Commun. 2016 Nov 07;7:13360
J:265602 Raj B, et al., Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis. Mol Cell. 2011 Sep 2;43(5):843-50
J:265608 Liu B, et al., RE1-Silencing Transcription Factor (Rest) is a Novel Regulator of Osteoblast Differentiation. J Cell Biochem. 2015 Sep;116(9):1932-8
J:265659 Nakano Y, et al., Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness. Cell. 2018 Jul 26;174(3):536-548.e21
J:273586 Lee JH, et al., Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element. Brain Res Mol Brain Res. 2000 Aug 14;80(1):88-98
J:273587 Shimojo M, et al., Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST. Mol Cell Biol. 1999 Oct;19(10):6788-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory