Sequence Detail

ID/Version

Q8VHS2 Q6ST50 B7ZC63 Q8BGR4 Q71JF2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Protein crumbs homolog 1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1405 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Crb1	crumbs family member 1, photoreceptor morphogenesis associated	66	113	3	28

Sequence references in MGI

J:73806 den Hollander AI, et al., Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev. 2002 Jan;110(1-2):203-7
J:85459 Mehalow AK, et al., CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Hum Mol Genet. 2003 Sep 1;12(17):2179-89
J:87371 Watanabe T, et al., Expression of a novel secretory form (Crb1s) of mouse Crumbs homologue Crb1 in skin development. Biochem Biophys Res Commun. 2004 Jan 9;313(2):263-70
J:92068 Van De Pavert SA, et al., Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci. 2004 Aug 15;117(Pt 18):4169-77
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
J:298908 Paniagua AE, et al., CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium. Sci Rep. 2015 Sep 25;5:14504