Sequence Detail

ID/Version

Q8VHN7 Q810D2 Q91ZS1 Q91ZS0 Q6ZQ69 Q810D3 (UniProt | EBI)

Last sequence update: 2002-03-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Adhesion G-protein coupled receptor V1 {ECO:0000305}; Short=ADGRV1 {ECO:0000305}; EC=3.4.-.- {ECO:0000269|PubMed:24962568};AltName: Full=G-protein coupled receptor 98;AltName: Full=Monogenic audiogenic seizure susceptibility

Provider

SWISS-PROT

Sequence

Polypeptide 6298 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adgrv1	adhesion G protein-coupled receptor V1	69	103	3	16

Sequence references in MGI

J:71344 Skradski SL, et al., A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron. 2001 Aug 30;31(4):537-44
J:73638 McMillan DR, et al., Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J Biol Chem. 2002 Jan 4;277(1):785-92
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:95518 Yagi H, et al., Vlgr1 knockout mice show audiogenic seizure susceptibility. J Neurochem. 2005 Jan;92(1):191-202
J:109595 McGee J, et al., The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci. 2006 Jun 14;26(24):6543-53
J:119820 Schwander M, et al., A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci. 2007 Feb 28;27(9):2163-75
J:122415 Michalski N, et al., Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci. 2007 Jun 13;27(24):6478-88
J:160677 Yang J, et al., Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010;6(5):e1000955
J:202979 Shin D, et al., Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Galphas/Galphaq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19101-6
J:209073 Zou J, et al., Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Hum Mol Genet. 2014 May 1;23(9):2374-90
J:218667 Chen Q, et al., Whirlin and PDZ domain-containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2. J Biol Chem. 2014 Dec 26;289(52):36070-88
J:236403 Morgan CP, et al., PDZD7-MYO7A complex identified in enriched stereocilia membranes. Elife. 2016 Aug 15;5:e18312
J:266109 Urano T, et al., GPR98/Gpr98 gene is involved in the regulation of human and mouse bone mineral density. J Clin Endocrinol Metab. 2012 Apr;97(4):E565-74
J:266111 Hu QX, et al., Constitutive Galphai coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein. J Biol Chem. 2014 Aug 29;289(35):24215-25
J:266117 Grati M, et al., Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network. J Neurosci. 2012 Oct 10;32(41):14288-93