Sequence Detail

ID/Version

Q8VEB1 O70297 O70292 (UniProt | EBI)

Last sequence update: 2004-05-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=G protein-coupled receptor kinase 5; EC=2.7.11.16;AltName: Full=G protein-coupled receptor kinase GRK5;

Provider

SWISS-PROT

Sequence

Polypeptide 590 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grk5	G protein-coupled receptor kinase 5	55	103	3	14

Sequence references in MGI

J:57925 Premont RT, et al., The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. J Biol Chem. 1999 Oct 8;274(41):29381-9
J:59179 Gainetdinov RR, et al., Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron. 1999 Dec;24(4):1029-36
J:96208 Walker JK, et al., G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L312-9
J:138970 Martini JS, et al., Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62
J:152271 Liu J, et al., GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. J Biol Chem. 2009 Jul 17;284(29):19564-71
J:167361 Cheng S, et al., GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity. J Biol Chem. 2010 Dec 31;285(53):41541-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89