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Sequence Detail
ID/Version
Q8VDK1 Q9R1N4 O88526 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2019-12-11
Sequence
description
from provider
RecName: Full=Deaminated glutathione amidase {ECO:0000303|PubMed:28373563}; Short=dGSH amidase {ECO:0000303|PubMed:28373563}; EC=3.5.1.128 {ECO:0000269|PubMed:28373563};AltName: Full=Nitrilase homolog 1 {ECO:0000305};Flags: Precursor;
Provider SWISS-PROT
Sequence
Polypeptide 323 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Nit1 nitrilase 1 6 7 9 16
Sequence references in MGI J:58686 Pekarsky Y, et al., Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8744-9
J:115052 Semba S, et al., Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. J Biol Chem. 2006 Sep 22;281(38):28244-53
J:149570 Zhang H, et al., Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. Int Immunol. 2009 Jun;21(6):691-703
J:161261 Sun J, et al., Nit1 and Fhit tumor suppressor activities are additive. J Cell Biochem. 2009 Aug 15;107(6):1097-106
J:242138 Peracchi A, et al., Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3233-E3242

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory