Sequence Detail

ID/Version

Q8VDD8 Q3U473 (UniProt | EBI)

Last sequence update: 2002-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=WASH complex subunit 1 {ECO:0000312|MGI:MGI:1916017};AltName: Full=WAS protein family homolog 1;

Provider

SWISS-PROT

Sequence

Polypeptide 475 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Washc1	WASH complex subunit 1	74	102	7	11

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:155753 Derivery E, et al., The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev Cell. 2009 Nov;17(5):712-23
J:163894 Monfregola J, et al., Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin. J Biol Chem. 2010 May 28;285(22):16951-7
J:202483 Xia P, et al., WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013 Oct 16;32(20):2685-96
J:217269 Piotrowski JT, et al., WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol. 2013 Mar;33(5):958-73
J:217315 Wang F, et al., WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes. Sci Rep. 2014;4:5596
J:217340 Graham DB, et al., Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. PLoS One. 2014;9(6):e98606
J:249681 Shin JJH, et al., TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi. Nat Cell Biol. 2017 Dec;19(12):1424-1432
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89