Sequence Detail

ID/Version

Q8VCF0 (UniProt | EBI)

Last sequence update: 2002-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Mitochondrial antiviral-signaling protein {ECO:0000305}; Short=MAVS {ECO:0000305};AltName: Full=CARD adapter inducing interferon beta; Short=Cardif;AltName: Full=Interferon beta promoter stimulator protein 1; Short=IP

Provider

SWISS-PROT

Sequence

Polypeptide 503 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mavs	mitochondrial antiviral signaling protein	83	97	3	27

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:144594 Sanada T, et al., FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 2008 Dec 5;283(49):33858-64
J:197368 Subramanian N, et al., The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell. 2013 Apr 11;153(2):348-61
J:257328 Liu Y, et al., The interaction between the helicase DHX33 and IPS-1 as a novel pathway to sense double-stranded RNA and RNA viruses in myeloid dendritic cells. Cell Mol Immunol. 2014 Jan;11(1):49-57
J:282875 Wang Y, et al., Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS. Nat Cell Biol. 2019 Nov;21(11):1346-1356
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87