Sequence Detail

ID/Version

Q8VBV4 Q8CCS5 A2RRI5 Q8VHP4 D3YUA5 (UniProt | EBI)

Last sequence update: 2018-04-25
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=F-box/WD repeat-containing protein 7 {ECO:0000305};AltName: Full=F-box and WD-40 domain-containing protein 7 {ECO:0000312|MGI:MGI:1354695};AltName: Full=F-box protein FBW7 {ECO:0000305};AltName: Full=F-box protein Fbxw6 {ECO:0000303|PubMed:1

Provider

SWISS-PROT

Sequence

Polypeptide 710 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fbxw7	F-box and WD-40 domain protein 7	94	105	3	56

Sequence references in MGI

J:71503 Gupta-Rossi N, et al., Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem. 2001 Sep 14;276(37):34371-8
J:73276 Maruyama S, et al., Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Genomics. 2001 Dec;78(3):214-22
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:251942 Fukushima H, et al., NOTCH2 Hajdu-Cheney Mutations Escape SCF(FBW7)-Dependent Proteolysis to Promote Osteoporosis. Mol Cell. 2017 Nov 16;68(4):645-658.e5
J:252001 Biswas M, et al., The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J Biol Chem. 2011 Nov 11;286(45):39282-9
J:271692 Zhao X, et al., Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBalpha Degradation. Cell. 2016 Jun 16;165(7):1644-1657