Sequence Detail

ID/Version

Q8R5M8 Q8R4L1 Q80VG4 Q8K3T6 Q7TNL1 Q9QYL5 Q9Z2H8 Q9QYL6 Q6F3J3 (UniProt | EBI)

Last sequence update: 2007-06-26
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cell adhesion molecule 1 {ECO:0000305};AltName: Full=Immunoglobulin superfamily member 4; Short=IgSF4;AltName: Full=Nectin-like protein 2; Short=NECL-2;AltName: Full=Spermatogenic immunoglobulin superfamily; Short=SgI

Provider

SWISS-PROT

Sequence

Polypeptide 456 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cadm1	cell adhesion molecule 1	73	118	4	30

Sequence references in MGI

J:78720 Biederer T, et al., SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science. 2002 Aug 30;297(5586):1525-31
J:79804 Fukami T, et al., Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene. Gene. 2002 Jul 24;295(1):7
J:83925 Fujita E, et al., RA175, which is the mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer, is a cell adhesion molecule. Exp Cell Res. 2003 Jul 1;287(1):57-66
J:85426 Shingai T, et al., Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem. 2003 Sep 12;278(37):35421-7
J:90387 Ito A, et al., Contribution of the SgIGSF adhesion molecule to survival of cultured mast cells in vivo. Biochem Biophys Res Commun. 2004 Jun 18;319(1):200-6
J:96462 Fujita E, et al., Distribution of RA175/TSLC1/SynCAM, a member of the immunoglobulin superfamily, in the developing nervous system. Brain Res Dev Brain Res. 2005 Feb 8;154(2):199-209
J:99380 Zhou Y, et al., Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochim Biophys Acta. 2005 May 20;1669(2):142-54
J:108386 van der Weyden L, et al., Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. Mol Cell Biol. 2006 May;26(9):3595-609
J:108395 Yamada D, et al., Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Mol Cell Biol. 2006 May;26(9):3610-24
J:114711 Boles KS, et al., The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood. 2005 Aug 1;106(3):779-86
J:129496 Fujita E, et al., Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily. Mol Cell Biol. 2006 Jan;26(2):718-26
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:152770 Takeuchi A, et al., CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J Immunol. 2009 Oct 1;183(7):4220-8
J:195238 Cheadle L, et al., The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization. J Cell Biol. 2012 Dec 10;199(6):985-1001
J:212409 Cortez VS, et al., CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection. J Exp Med. 2014 Apr 7;211(4):623-33
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89