Sequence Detail

ID/Version

Q8R5F7 Q99KS4 Q8VE79 Q8K5C7 Q8BYC9 Q8BZ01 A2AUY7 Q8R144 Q3U6S2 Q9D2Z5 Q68EM4 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interferon-induced helicase C domain-containing protein 1; EC=3.6.4.13 {ECO:0000250|UniProtKB:Q9BYX4};AltName: Full=Helicase with 2 CARD domains; Short=Helicard;AltName: Full=Interferon induced with helicase C domain protein

Provider

SWISS-PROT

Sequence

Polypeptide 1025 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ifih1	interferon induced with helicase C domain 1	101	99	3	20

Sequence references in MGI

J:76465 Kovacsovics M, et al., Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation. (Erratum v. 12, pg. 1633). Curr Biol. 2002 May 14;12(10):838-43
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:137522 Kato H, et al., Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006 May 4;441(7089):101-5
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:168254 Zust R, et al., Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nat Immunol. 2011 Feb;12(2):137-43
J:182522 Berke IC, et al., MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. EMBO J. 2012;31(7):1714-26
J:183219 Loo YM, et al., Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol. 2008 Jan;82(1):335-45
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89