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Sequence Detail
Q8R4X1 A1L3S2 (UniProt | EBI) Last sequence update: 2002-06-01
Last annotation update: 2020-06-17
from provider
RecName: Full=Alkaline ceramidase 1 {ECO:0000305}; Short=AlkCDase 1; Short=Alkaline CDase 1; Short=maCER1; EC=3.5.1.- {ECO:0000250|UniProtKB:Q8TDN7}; EC= {ECO:0000269|PubMed:12783875, ECO:0000269|PubMed:2712
Polypeptide 273 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Acer1 alkaline ceramidase 1 26 71 9 4
Sequence references in MGI J:84882 Mao C, et al., Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J Biol Chem. 2003 Aug 15;278(33):31184-91
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:235775 Liakath-Ali K, et al., Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure. J Pathol. 2016 Jul;239(3):374-83
J:252017 Lin CL, et al., Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 Nov 14;9(5):1488-1500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory