Sequence Detail

ID/Version

Q8R4X1 A1L3S2 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Alkaline ceramidase 1 {ECO:0000305}; Short=AlkCDase 1; Short=Alkaline CDase 1; Short=maCER1; EC=3.5.1.- {ECO:0000250|UniProtKB:Q8TDN7}; EC=3.5.1.23 {ECO:0000269|PubMed:12783875, ECO:0000269|PubMed:2712

Provider

SWISS-PROT

Sequence

Polypeptide 273 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Acer1	alkaline ceramidase 1	29	98	3	4

Sequence references in MGI

J:84882 Mao C, et al., Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. J Biol Chem. 2003 Aug 15;278(33):31184-91
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:235775 Liakath-Ali K, et al., Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure. J Pathol. 2016 Jul;239(3):374-83
J:252017 Lin CL, et al., Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 Nov 14;9(5):1488-1500