Sequence Detail

ID/Version

Q8R4P5 Q9D435 Q7TQB2 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2025-04-09

Sequence description from provider

RecName: Full=Transmembrane channel-like protein 1 {ECO:0000303|PubMed:30138589};AltName: Full=Beethoven protein {ECO:0000303|PubMed:11850623};AltName: Full=Deafness protein {ECO:0000303|PubMed:11850618};AltName: Full=Transmembrane cochlear-expressed prot

Provider

SWISS-PROT

Sequence

Polypeptide 757 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tmc1	transmembrane channel-like gene family 1	39	103	3	25

Sequence references in MGI

J:75103 Vreugde S, et al., Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet. 2002 Mar;30(3):257-8
J:75142 Kurima K, et al., Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Nat Genet. 2002 Mar;30(3):277-84
J:84240 Keresztes G, et al., TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics. 2003 Jun 17;4(1):24
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:201662 Pan B, et al., TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron. 2013 Aug 7;79(3):504-15
J:214830 Maeda R, et al., Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12907-12
J:244562 Giese APJ, et al., CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun. 2017 Jun 29;8(1):43
J:249939 Cunningham CL, et al., The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells. Elife. 2017 May 15;6:e24318
J:257320 Erickson T, et al., Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife. 2017 May 23;6:e28474
J:269778 Pan B, et al., TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 2018 Aug 22;99(4):736-753.e6
J:307668 Liang X, et al., CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells. Neuron. 2021 Jul 7;109(13):2131-2149.e15
J:344636 Fettiplace R, et al., The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2210849119
J:349395 Lee JH, et al., The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell. Nat Commun. 2024 Jan 16;15(1):526