Sequence Detail

ID/Version

Q8R4D1 Q5WA59 Q8BIH8 Q3UPR4 A2A465 Q8BJ27 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sodium/hydrogen exchanger 8;AltName: Full=Na(+)/H(+) exchanger 8; Short=NHE-8;AltName: Full=Solute carrier family 9 member 8;

Provider

SWISS-PROT

Sequence

Polypeptide 576 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc9a8	solute carrier family 9 (sodium/hydrogen exchanger), member 8	62	98	3	135

Sequence references in MGI

J:82496 Goyal S, et al., Renal expression of novel Na+/H+ exchanger isoform NHE8. Am J Physiol Renal Physiol. 2003 Mar;284(3):F467-73
J:96197 Nakamura N, et al., Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem. 2005 Jan 14;280(2):1561-72
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:191151 Xu H, et al., Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G335-43
J:194858 Xu H, et al., NHE8 plays important roles in gastric mucosal protection. Am J Physiol Gastrointest Liver Physiol. 2013 Feb 1;304(3):G257-61
J:202781 Liu C, et al., NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion. Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C121-8
J:223665 Xu H, et al., Loss of NHE8 expression impairs ocular surface function in mice. Am J Physiol Cell Physiol. 2015 Jan 1;308(1):C79-87
J:223855 Xu H, et al., Disruption of NHE8 expression impairs Leydig cell function in the testes. Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C330-8
J:245977 Oberheide K, et al., Loss of the Na+/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation. J Biol Chem. 2017 Jun 30;292(26):10845-10854
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333167 Xia CH, et al., Essential function of NHE8 in mouse retina demonstrated by AAV-mediated CRISPR/Cas9 knockdown. Exp Eye Res. 2018 Nov;176:29-39