Sequence Detail

ID/Version

Q8R418 Q8R418 (UniProt | EBI)

Last sequence update: 2009-09-01 Last annotation update: 2012-11-28

Sequence description from provider

RecName: Full=Endoribonuclease Dicer; EC=3.1.26.-;AltName: Full=Double-strand-specific ribonuclease mDCR-1;

Provider

SWISS-PROT

Sequence

Polypeptide 1916 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dicer1	dicer 1, ribonuclease type III	100	13	5	25

Sequence references in MGI

J:74999 Nicholson RH, et al., Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease III ortholog involved in RNA interference. Mamm Genome. 2002 Feb;13(2):67-73
J:92289 Doi N, et al., Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol. 2003 Jan 8;13(1):41-6
J:132169 Du Z, et al., Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2391-6