Sequence Detail

ID/Version

Q8R2F2 Q3TR85 Q78JJ1 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; EC=1.14.18.5 {ECO:0000269|PubMed:11937514, ECO:0000269|PubMed:14731113, ECO:0000269|PubMed:16571104}; EC=1.14.19.17 {ECO:0000269|PubMed:14731113, ECO:0000269|PubMed:1657

Provider

SWISS-PROT

Sequence

Polypeptide 323 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Degs2	delta 4-desaturase, sphingolipid 2	12	98	3	7

Sequence references in MGI

J:93293 Omae F, et al., Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2. FEBS Lett. 2004 Nov 8;576(1-2):63-7
J:93864 Ternes P, et al., Identification and characterization of a sphingolipid delta 4-desaturase family. J Biol Chem. 2002 Jul 12;277(28):25512-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116414 Enomoto A, et al., Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5. Biochem J. 2006 Jul 15;397(2):289-95