Sequence Detail

ID/Version

Q8R216 D3Z1D9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=NAD-dependent protein lipoamidase sirtuin-4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000303|PubMed:25525879}; EC=2.3.1.- {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000305|PubMed:25525879};AltName: Full=NAD-dependent ADP-ribo

Provider

SWISS-PROT

Sequence

Polypeptide 333 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sirt4	sirtuin 4	70	99	3	25

Sequence references in MGI

J:129427 Haigis MC, et al., SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 8;126(5):941-54
J:197042 Jeong SM, et al., SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013 Apr 15;23(4):450-63
J:198927 Csibi A, et al., The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 May 9;153(4):840-54
J:199252 Laurent G, et al., SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 6;50(5):686-98
J:206091 Laurent G, et al., SIRT4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation. Mol Cell Biol. 2013 Nov;33(22):4552-61
J:219204 Mathias RA, et al., Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell. 2014 Dec 18;159(7):1615-25
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89