Sequence Detail

ID/Version

Q8R1P5 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Potassium channel subfamily K member 13 {ECO:0000303|PubMed:35353387};AltName: Full=Tandem pore domain halothane-inhibited potassium channel 1; Short=THIK-1 {ECO:0000303|PubMed:35353387};

Provider

SWISS-PROT

Sequence

Polypeptide 405 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnk13	potassium channel, subfamily K, member 13	33	98	4	9

Sequence references in MGI

J:256020 Madry C, et al., Microglial Ramification, Surveillance, and Interleukin-1beta Release Are Regulated by the Two-Pore Domain K(+) Channel THIK-1. Neuron. 2018 Jan 17;97(2):299-312.e6
J:325990 Drinkall S, et al., The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation. Glia. 2022 Jul;70(7):1301-1316
J:345713 Rifat A, et al., Differential contribution of THIK-1 K(+) channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia. J Neuroinflammation. 2024 Feb 26;21(1):58
J:355630 Izquierdo P, et al., Synapse development is regulated by microglial THIK-1 K(+) channels. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2106294118