Sequence Detail

ID/Version

Q8R1M0 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Abasic site processing protein HMCES {ECO:0000305}; EC=4.-.-.- {ECO:0000250|UniProtKB:Q96FZ2};AltName: Full=Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Short=ES cell-specific 5hmC-binding protein;Alt

Provider

SWISS-PROT

Sequence

Polypeptide 353 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hmces	5-hydroxymethylcytosine (hmC) binding, ES cell specific	36	97	3	23

Sequence references in MGI

J:254234 Kweon SM, et al., Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease. Cell Rep. 2017 Oct 10;21(2):482-494
J:285016 Shukla V, et al., HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Mol Cell. 2020 Jan 16;77(2):384-394.e4
J:343116 Wu L, et al., HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Genes Dev. 2022 Apr 1;36(7-8):433-450