Sequence Detail

ID/Version

Q8R104 C6ZII7 B9W0A9 Q9EPA8 (UniProt | EBI)

Last sequence update: 2014-03-19
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NAD-dependent protein deacetylase sirtuin-3; EC=2.3.1.286 {ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:21858060, ECO:0000269|PubMed:26620563, ECO:0000305|PubMed:17923681, ECO:0000305|PubMed:18794531, ECO:0000305|PubMed:2

Provider

SWISS-PROT

Sequence

Polypeptide 334 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sirt3	sirtuin 3	65	101	3	26

Sequence references in MGI

J:65632 Yang YH, et al., Cloning and characterization of two mouse genes with homology to the yeast sir2 gene. Genomics. 2000 Nov 1;69(3):355-69
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:129009 Lombard DB, et al., Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec;27(24):8807-14
J:142586 Ahn BH, et al., A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52
J:147454 Cooper HM, et al., A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS One. 2009;4(3):e4986
J:163964 Jin L, et al., Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci. 2009 Mar;18(3):514-25
J:168095 Tao R, et al., Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell. 2010 Dec 22;40(6):893-904
J:176493 Finley LW, et al., Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One. 2011;6(8):e23295
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:208950 Jing E, et al., Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 2013 Oct;62(10):3404-17
J:230048 Novgorodov SA, et al., SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22;291(4):1957-73
J:257325 Peserico A, et al., A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell Mol Life Sci. 2013 Jun;70(11):2015-29
J:276379 Hallows WC, et al., Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10230-10235
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:337416 Perez-Hernandez M, et al., Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC. Circulation. 2022 Sep 13;146(11):851-867
J:338255 Cheng L, et al., Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis. Hepatology. 2023 Feb 22;