Sequence Detail

ID/Version

Q8K4Q0 Q8C9W9 Q9D4H3 Q8CBY4 Q8CDY8 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Regulatory-associated protein of mTOR {ECO:0000305}; Short=Raptor {ECO:0000303|PubMed:33495318};AltName: Full=p150 target of rapamycin (TOR)-scaffold protein {ECO:0000303|PubMed:12150926};

Provider

SWISS-PROT

Sequence

Polypeptide 1335 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rptor	regulatory associated protein of MTOR, complex 1	45	106	3	64

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:136666 Gwinn DM, et al., AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008 Apr 25;30(2):214-26
J:137592 Guertin DA, et al., Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec;11(6):859-71
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:161033 Hara K, et al., Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002 Jul 26;110(2):177-89
J:164024 Takai H, et al., Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 2010 Sep 15;24(18):2019-30
J:238485 Dai Q, et al., Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice. J Biol Chem. 2017 Jan 06;292(1):196-204
J:276425 Xie F, et al., Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation. Front Physiol. 2019;10:250
J:277654 Jewell JL, et al., GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 May 21;8:e43038
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302579 De Gregorio D, et al., Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2020705118
J:303713 Van Nostrand JL, et al., AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. Genes Dev. 2020 Oct 1;34(19-20):1330-1344