Sequence Detail

ID/Version

Q8K4K6 Q9QXM8 Q9D3K1 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Pantothenate kinase 1; Short=mPank; Short=mPank1; EC=2.7.1.33 {ECO:0000269|PubMed:10625688, ECO:0000269|PubMed:12095677, ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:17379144, ECO:0000269|PubMed:20559429, ECO:00002

Provider

SWISS-PROT

Sequence

Polypeptide 548 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pank1	pantothenate kinase 1	41	100	4	17

Sequence references in MGI

J:74934 Rock CO, et al., Pantothenate kinase regulation of the intracellular concentration of coenzyme A. J Biol Chem. 2000 Jan 14;275(2):1377-83
J:77934 Rock CO, et al., The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes. Gene. 2002 May 29;291(1-2):35-43
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102155 Zhang YM, et al., Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters. J Biol Chem. 2005 Sep 23;280(38):32594-601
J:161798 Leonardi R, et al., Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state. PLoS One. 2010;5(6):e11107
J:189609 Garcia M, et al., Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism. PLoS One. 2012;7(7):e40871
J:195468 Alfonso-Pecchio A, et al., Compartmentalization of mammalian pantothenate kinases. PLoS One. 2012;7(11):e49509
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302451 Zhang YM, et al., Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. Chem Biol. 2007 Mar;14(3):291-302