Sequence Detail

ID/Version

Q8K4F6 Q8C568 Q80WG3 Q3U0Q8 (UniProt | EBI)

Last sequence update: 2006-11-28
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=28S rRNA (cytosine-C(5))-methyltransferase {ECO:0000305}; EC=2.1.1.- {ECO:0000305|PubMed:31722427};AltName: Full=NOL1/NOP2/Sun domain family member 5 {ECO:0000303|PubMed:30485550, ECO:0000303|PubMed:31174389};AltName: Full=Williams-B

Provider

SWISS-PROT

Sequence

Polypeptide 465 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nsun5	NOL1/NOP2/Sun domain family, member 5	31	100	4	15

Sequence references in MGI

J:78054 Merla G, et al., Identification of additional transcripts in the Williams-Beuren syndrome critical region. Hum Genet. 2002 May;110(5):429-38
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:271670 Zhang T, et al., Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells. Glia. 2019 Apr;67(4):688-702
J:278623 Yuan Z, et al., Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase. Cells. 2019 Jun 6;8(6):552
J:282264 Chen P, et al., Expression of the RNA methyltransferase Nsun5 is essential for developing cerebral cortex. Mol Brain. 2019 Aug 28;12(1):74
J:287064 Heissenberger C, et al., Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth. Nucleic Acids Res. 2019 Dec 16;47(22):11807-11825